Ana Coutinho
Assistant Professor (FCUL)

Research Activities
Unraveling the influence of lipid membranes on the molecular mechanism of fibril formation by amyloidogenic proteins/peptides.
Using fluorescence resonance energy transfer (FRET) to study the conformational dynamics of membrane proteins.
Development of new antimicrobial peptides that combat drug-resistant bacteria and biofilms.

Selected Publications
Videira MAM, Lobo SAL, Silva LSO, Palmer DJ, Warren MJ, Prieto M, Coutinho A, Sousa FL, Fernandes F, Saraiva, LM (2018) Staphylococcus aureus haem biosynthesis and acquisition pathways are linked through monooxygenase IsdG, Mol. Microbio. in press, doi: 10.1111/mmi.14060

Sarmento MJ, Coutinho A, Fedorov A, Prieto M, Fernandes F (2017) Membrane order is a key regulator of divalent cation-induced clustering of PI(3,5)P2 and PI(4,5)P2, Langmuir 33: 12463-12477, doi: 10.1021/acs.langmuir.7b00666

Sarmento MJ, Pinto SN, Coutinho A, Prieto M, Fernandes F (2016) Accurate quantification of inter-domain partition coefficients in GUVs exhibiting lipid phase coexistence. RSC Advances. 6: 66641-66649, doi:10.1039/c6ra13170k

Fernandes F, Coutinho A, Prieto M, Loura LMS (2015) Electrostatically driven lipid-protein interaction: Answers from FRET. Biochim. Biophys. Acta – Biomembranes (Special Issue: “Lipid-Protein Interactions”) 1848: 1837-1848, doi: 10.1016/j.bbamem.2015.02.023

Melo AM, Fedorov A, Prieto M, Coutinho A (2014) Exploring homo-FRET to quantify the oligomer stoichiometry of membrane-bound proteins involved in a cooperative partition equilibrium. Phys.Chem.Chem.Phys. 16: 18105-18117, doi: 10.1039/c4cp00060a

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