Arsénio M. Fialho
Associate Professor with Habilitation

Research Activities
His research is focused on the study of bacterial proteins as novel anticancer agents. Studies aiming to elucidate the cellular and molecular effects of treating cancer cells with azurin, a cupredoxin produced by P. aeruginosa. His research interests also include the study of trimeric autotransporter adhesins as key virulence determinants in members of the Burkholderia cepacia complex, a group of bacteria that have emerged as opportunistic pathogens among individuals with cystic fibrosis. (Learn more)

Selected Publications
Bernardes N, Garizo AR, Pinto SN, Caniço B, Perdigão C, Fernandes F, Fialho AM (2018) Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs. Cell Cycle, 17(13):1649-1666, doi: 10.1080/15384101.2018.1489178

Mil-Homens D, Barahona S, Moreira RN, Silva IJ, Pinto SN, Fialho AM, Arraiano CM (2018) The stress-response protein BolA influences fitness and promotes Salmonella Typhimurium virulence. Applied and Environmental Microbiology 84(8), doi: 10.1128/AEM.02850-17

Silva LO, Nobre LS, Mil-Homens D, Fialho AM, Saraiva LM (2018) Repair of Iron centers RIC protein contributes to the virulence of Staphylococcus aureus. Virulence, 9(1):312-317, doi: 10.1080/21505594.2017.1389829

Santos R, Costa C, Mil-Homens D, Romão D, de Carvalho CC, Pais P, Mira NP, Fialho AM, Teixeira MC (2017) The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata. Cellular Microbiology, 19(5), doi: 10.1111/cmi.12686

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM (2017) Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation. Cellular Microbiology, 19(4), doi: 10.1111/cmi.12677

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