Cláudia Lobato da Silva
Assistant Professor

Research Activities
My research interests are focused on the ex-vivo expansion of human stem cells, namely hematopoietic stem/progenitor cells and mesenchymal stem/stromal cells, Cellular Therapies with human stem cells and bioreactors for stem cell cultivation. We have also been exploiting genetic engineering tools to improve human stem cell features for therapeutic use (e.g. angiogenic therapies).

Selected Publications
Cabral JMS, Lobato da Silva, C (Eds.) (2018) Bioreactors for Stem Cell Expansion and Differentiation. CRC Press, ISBN 9781498795906

Serra J, Alves CPA, Brito L, Monteiro GA, Cabral JMS, Prazeres DMF, da Silva CL (2018) Engineering of human mesenchymal stem/stromal cells (MSC) with VEGF-encoding minicircles for angiogenic ex vivo gene therapy, Hum Gene Ther., doi: 10.1089/hum.2018.154. [Epub ahead of print]

Costa MHG, de Soure AM, Cabral JMS, Ferreira FC, da Silva CL (2018) Hematopoietic Niche - Exploring Biomimetic Cues to Improve the Functionality of Hematopoietic Stem/Progenitor Cells, Biotechnol J. 13(2), doi: 10.1002/biot.201700088.

de Soure AM, Fernandes-Platzgummer A, Moreira F, Lilaia C, Liu SH, Ku CP, Huang YF, Milligan W, Cabral JMS, da Silva CL (2017) Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells, J Tissue Eng Regen Med. 11:1630-1640, doi: 10.1002/term.2200.

Mizukami A, Fernandes-Platzgummer A, Carmelo JG, Swiech K, Covas DT, Cabral JM, da Silva CL (2016) Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells, Biotechnol J.,11:1048-59, doi: 10.1002/biot.201500532.

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