Jorge Humberto Gomes Leitão
Associate Professor

Research Activities
Post-transcription regulation of bacterial gene expression, focusing on the roles played by small non-coding regulatory RNAs (sRNAs) and the RNA chaperones Hfq and Hfq2 on the biology and pathogenesis of Burkholderia cepacia complex bacteria.
Exopolysacharide biosynthesis by Gram-negative bacteria, focusing on the functional analysis of enzymes and proteins involved in biosynthesis and regulation.
Molecular characterization of microbial populations of ecological, industrial or health interest.
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Selected Publications
SA Sousa, AMM Seixas, JH Leitão. 2018. Post-genomic approaches and bioinformatics tools to advance the development of vaccines against bacteria of the Burkholderia cepacia complex. Vaccines 6, 34; doi:10.3390/vaccines6020034

P Martina, M Leguizamon, CI Prieto, SA Sousa, P Montanaro, WO Draghi, M Stämmler, M Bettiol, CCCR de Carvalho, J Palau, C Figoli, F Alvarez, S Benetti, S Lejona, C Vescina, J Ferreras, P Lasch, A Lagares, A Zorreguieta, JH Leitão, OM Yantorno, A Bosch. 2017. Burkholderia puraquae sp. nov., a novel Burkholderia cepacia complex species from hospital settings and agricultural soils. International Journal of Systematic and Evolutionary Microbiology 68:14-20 doi:10.1099/ijsem.0.002293

J.M.S. Cardoso, S.I. Guerreiro, A. Lourenço, M. M. Alves, M.F. Montemor, N.P. Mira, J.H. Leitão*, M.F.N.N. Carvalho*. 2017. Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus. PloS One doi: 10.1371/journal.pone.0177355

S.A. Sousa, J.R. Feliciano, T. Pita, S.I. Guerreiro, J.H. Leitão. 2017. Burkholderia cepacia complex virulence gene expression regulation: a review. Genes 8:43. doi: 10.3390/genes8010043

A.S. Moreira, D. Mil-Homens, S.A. Sousa, C.P. Coutinho, A. Pinto-de-Oliveira, C.G. Ramos, S.C. dos Santos, A.M. Fialho, J.H. Leitão, I. Sá-Correia. 2017. Variation of Burkholderia cenocepacia virulence potential during long-term cystic fibrosis chronic lung infection. Virulence 8 (6) : 782-796. doi: 10.1080/21505594.2016.1237334

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