José António Leonardo dos Santos
Assistant Professor

Research Activities
My current research is focused on plasmid DNA (pDNA) manufacturing processes (production, separation, purification, quality control and monitoring) for application in gene therapy or DNA vaccination. The utilization of membrane processes (ultra and microfiltration) and the development of alternative methods to alkaline lysis for plasmid release are under research. The development of alternative microbial GRAS (generally recognized as safe) platforms for pDNA and lactic acid production (biorefinery) is other goal of my research.

Selected Publications
Marques S., Gírio FM, Santos JAL, Roseiro JC, (2017) Pulsed fed-batch strategy towards intensified process for lactic acid production using recycled paper sludge, Biomass Convers. Biorefin., 7, 127-137, doi: 10.1007/s13399-016-0211-0

Marques S, Gírio FM, Roseiro JC, Santos JAL (2017) Lactic acid production from recycled paper sludge: process intensification by running fed-batch into a membrane-recycle bioreactor, Biochem. Eng. J., 120, 63–72, doi: 10.1016/j.bej.2016.12.021

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