Manuel Prieto
Full Professor



Research Activities

Research is on molecular and cell biophysics, in order to obtain structural and dynamic information, using advanced fluorescence time-resolved anisotropy and energy transfer (FRET), as well as state-of-the art fluorescence microscopy (FCS, FLIM, FRAP, FAIM). Topics presently under study are the detection and characterization of membrane domains in several lipid systems (oxidized lipids, sphingolipids, bile acids) and lipid-protein interaction (amyloid proteins and ion channels).

Selected Publications

Dao, T., Fernandes, F, Fauquignon, M., Ibarboure, E., Prieto, M.,   Le Meins, J.-F. (2018). The combination of block copolymers and phospholipids to form Giant Hybrid Unilamellar Vesicles (GHUVs) does not systematically lead to “intermediate” membrane properties. Soft Matter 14, 6476-6484. DOI: 10.1039/c8sm00547h

Cabre E.J., Martínez-Calle M, Prieto M., Fedorov A., Olmeda B., Loura, M.S., Pérez-Gil J. (2018). Homo- and hetero-oligomerization of hydrophobic pulmonary surfactant proteins SP-B and SP-C in surfactant phospholipid membranes. J. Biol. Chem. 293, 9399-9411, DOI 10.1074/jbc.RA117.000222

Sarmento M., Coutinho A., Fedorov A., Prieto M.,Fernandes F. (2017). Membrane order is a key regulator of divalent cation-induced clustering of PI(3,5)P2 and PI(4,5)P2. 2017, Langmuir 33, 12463-12477

Varela A. R. P., Ventura A. E., Carreira A. C., Fedorov A.,   Futerman A. H.,   Prieto M., Silva L.C. (2017).  Pathological levels of Glucosylceramide change the biophysical properties of artificial and cell membranes.. Phys. Chem. Chem. Phys. 19, 340-346

Dao T., Fernandes F., Ibarboure E., Ferji K., Prieto M., Sandre O., Le Meins J.-F. (2017). Modulation of Phase Separation at micron scale and nanoscale in Hybrid Polymer/Lipid Giant Unilamellar Vesicles (GHUVs) Soft Matter, 2017,13, 627-637

 

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