Maria Margarida Diogo
Assistant Professor

Research Activities
My current research activities are focused on the development of neural and cardiac differentiation models from human pluripotent stem cells (hPSCs), in particular human induced pluripotent stem cells (hiPSCs), and their application for disease modelling, drug screening and toxicology assays. To support these activities, I am also interested in developing scalable bioprocesses for the large scale production of hiPSC derivatives.

Selected Publications
Miranda CC, Fernandes TG, Pinto SN, Prieto M, Diogo MM, Cabral JMS (2018) A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies, Toxicol. Lett. 294: 51-60. doi: 10.1016/j.toxlet.2018.05.018. 

Dias TP, Pinto SN, Santos JI, Fernandes TG, Fernandes F, Diogo MM, Prieto M, Cabral JMS (2018) Biophysical study of human induced Pluripotent Stem Cell-Derived cardiomyocyte structural maturation during long-term culture, Biochem. Biophys. Res. Commun. 499(3): 611-617. doi: 10.1016/j.bbrc.2018.03.198.

Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV (2017) Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System, Stem Cell Rep. 8(6): 1770-1783. doi: 10.1016/j.stemcr.2017.04.027.

Badenes SM, Fernandes TG, Cordeiro CSM, Boucher S, Kuninger D, Vemuri MC, Diogo MM, Cabral JMS (2016) Defined essential 8™ medium and vitronectin efficiently support scalable xeno-free expansion of human induced pluripotent stem cells in stirred microcarrier culture systems, PLoS One 11(5): e0151264. doi: 10.1371/journal.pone.0151264.

Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR, Rodrigues GMC, Haupt S, Rombo DM, Armstrong J, Sebastião AM, Gribnau J, Garcia-Cazorla A, Brüstle O, Henrique D, Cabral JMS, Diogo MM (2015) Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells, Biotech. J. 10(10): 1587-1588. doi: 10.1002/biot.201400751.

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