Amir Javidanbardan
PhD Student

Research Activities

I am mainly interested and skilled in pharmaceutical bioprocess development in both areas of fermentation and downstream processing. At the moment, I am one of 15 Early Stage Reseachers (ESRs) in the International Training Network (ITN) CODOBIO – Continuous Downstream Processing of Biologics - funded in the frame of Marie Skłodowska-Curie Actions. I am mainly carrying out my project in Institute Superior Técnico via the collaboration between IBB and INESC. My project aims to develop microfluidic devices for continuous chromatography to intensify process design and development of the downstream processing of biological products.

Selected Publications

Hosseini SN, Javidanbardan A, Khatami M (2019) Accurate and cost‐effective prediction of HBsAg titer in industrial-scale fermentation process of recombinant Pichia pastoris by using neural network based soft sensor, Biotechnol. Appl. Biochem. doi: 10.1002/bab.1785

Khosravi R, Hosseini SN, Javidanbardan A, Khatami M, Kaghazian H, Mousavi Nasab SD (2019) Optimization of non-detergent treatment for enveloped virus inactivation using the Taguchi design of experimental methodology (DOE), Prep. Biochem. Biotechnol. 49: 686-694, doi: 10.1080/10826068.2019.1599398

Kimia Z, Hosseini SN, Ashraf Talesh SS, Khatami M, Kavianpour A, Javidanbardan A (2019) A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving recombinant HBsAg homogeneity by removing associated aggregates, J. Chromatogr. B. 1113: 20–29, doi:10.1016/j.jchromb.2019.03.009

Javidanbardan A (2018) Protein refolding on ion-exchange chromatography: improving total mass recovery and investigating separation factors of folded and unfolded states, European Biotechnology Congress 2018, Athens, Greece | April 2018 (Oral Presentation). Abstr / J. Biotechnol. 280: S15. doi: 10.1016/j.jbiotec.2018.06.043

Mostafaei M, Hosseini SN, Khatami M, Javidanbardan A, Sepahy AA, Asadi E (2018) Isolation of recombinant Hepatitis B surface antigen with antibody-conjugated superparamagnetic Fe3O4/SiO2 core-shell nanoparticles, Protein. Expr. Purif. 145: 1-6. doi: 10.1016/j.pep.2017.12.004

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