Bernardo Ribeiro da Cunha
PhD student

Research Activities

My research focus on establishing a platform for screening the antimicrobial activity and mode-of-action of novel antibiotics based on MIR spectroscopy. This includes bioassay optimization for high throughput screening, the application of multivariate analysis ranging from chemometrics to neural networks and culminates in building a library of antibiotic responses for various bacterial models.

Selected Publications

Sales KC, Rosa F, Cunha BR, Sampaio PN, Lopes MB, Calado CRC (2017). Metabolic profiling of recombinant Escherichia coli cultivations based on high-throughput FT-MIR spectroscopic analysis, Biotechnol. Prog. 33(2):285-298, doi: 10.1002/btpr.2378

Cunha BR, Russo A, Fonseca LP, Calado CRC (2017). Optimization of a Bioassay to Evaluate Escherichia coli Stress Responses, IEEE Enberg, ISBN: 978-1-5090-4801-4.

Cunha BR; Fonseca LP, Calado CRC (2017). High-Throughput Bioassay for Mechanism of Action Determination of Antibacterial Drugs, IEEE Enberg, ISBN: 978-1-5090-4801-4.

Sales KC, Cunha BR, Calado CRC (2017). Biopharmaceuticals Process Monitoring Based on Infrared Spectroscopy According to Quality by Design, IEEE Enberg, ISBN:978-1-5090-4801-4.

Rosa F, Sales KC, Cunha BR, Couto A, Lopes MB, Calado CRC (2015). A comprehensive high-throughput FTIR spectroscopy-based method for evaluating the transfection event: estimating the transfection efficiency and extracting associated metabolic responses, Anal. Bioanal. Chem. 407(26):8097-8108, doi: 10.1007/s00216-015-8983-9.

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