Eduardo Brás
PhD Student

Research Activities

My research is being developed from a collaboration between IBB and INESC Microsystems and Nanotechnologies, under the Advanced Integrated Microsystems doctoral program. My work is supervised by Professor João Pedro Conde and Professor Pedro Fernandes and focuses on the application of enzymatic reactions in tailored made microfluidic chips. Two potential applications will be studied: (i) biosensing of metabolites (in plants, animals and humans); (ii) screening of production conditions for high value added biotechnological products.
In addition, the integration of additional processing modules to the microfluidic microreactor will be studied: (i) sample preparation; (ii) downstream separation. In the past I've worked on the development of microfluidic reactors for the cultivation of yeast cells and on the development of a microfluidic approach to optimise the purification of biomolecules through the use of aqueous two-phase systems.
Selected Publications

Bras, E. J. S., Soares, R. R., Azevedo, A. M., Fernandes, P., Arévalo-Rodríguez, M., Chu, V., ... & Aires-Barros, M. R. (2017). A multiplexed microfluidic toolbox for the rapid optimization of affinity-driven partition in aqueous two phase systems. Journal of Chromatography A, 1515, 252-259.

Bras, E.J.S., Chu, V., Aires-Barros, M.R., Conde, J.P., Fernandes, P., “A microfluidic platform for physical entrapment of yeast cells with continuous production of invertase”, J. Chem. Technol. Biotechnol. 92 (2017) 334-341. doi: 10.1002/jctb.5010

Development of a Point-of-Care Platform for Plant Health Assesment: A Microfluidic Approach, Oral Presentation at the 32nd Edition of the Eurosensors Conference, 2018;

Rapid and multiplexed screening of aqueous two-phase systems for the affinity driven partition of biopharmaceuticals using a microfluidic toolbox, Oral Presentation at Anything But Conventional Chromatography, ESBES Workshop 2017;

Best poster award at the Microbiotec'17 conference in Porto for the work: "Affinity driven aqueous-two phase extraction of antibodies: a microfluidic approach."

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