Ana Fernandes-Platzgummer
Research Associate

Research Activities

My research addresses the development of efficient, scalable and cost-effective production processes for the large-scale ex-vivo expansion of human adult stem cells (namely hematopoietic stem/progenitor cells and mesenchymal stem/stromal cells) in controlled bioreactors.

Selected Publications

Mizukami A, Neto MSA, Moreira F, Fernandes-Platzgummer A, Huang Y-F, Milligan W, Cabral JMS, da Silva CL, Covas DT, Swiech K (2018) A fully-closed and automated hollow fiber bioreactor for clinical-grade manufacturing of human mesenchymal stem/stromal cells, Stem Cell Rev Rep 14(1):141-143, doi: 10.1007/s12015-017-9787-4.

de Soure AM, Fernandes-Platzgummer A, Moreira F, Lilaia C, Liu S-H, Ku C-P, Huang Y-F, Milligan W, Cabral JMS, da Silva CL (2017) Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells, J Tissue Eng Regen Med 11(5):1630-1640, doi: 10.1002/term.2200.

de Soure AM, Fernandes-Platzgummer A, da Silva CL, Cabral JMS (2016) Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells, J Biotechnol 236:88-109, doi: 10.1016/j.jbiotec.2016.08.007.

Mizukami A, Fernandes-Platzgummer A, Carmelo JG, Swiech K, Covas DT, Cabral JMS, da Silva CL (2016) Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells, Biotechnol J 11:1048-1059, doi: 10.1002/biot.201500532.

Fernandes-Platzgummer A, Diogo MM, Lobato da Silva C, Cabral JMS (2014) Maximizing Mouse Embryonic Stem Cell Production in a Stirred Tank Reactor by Controlling Dissolved Oxygen Concentration and Continuous Perfusion Operation, Biochem Eng J 82:81-90, doi: 10.1016/j.bej.2013.11.014.

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