Cláudia C. Miranda
Post-Doctoral Researcher

Research Activities
Human induced pluripotent stem cells (hiPSC) may be an ideal source for therapy, personalized drug development and disease modelling. However, to realize this enormous potential, it is necessary to develop robust and reproducible bioprocesses for hPSCs expansion and controlled differentiation at large scale. The main aim of my research is the development of a scalable and cost-effective culture platforms for expansion of hPSCs and their controlled neural and cardiac differentiation under xeno-free chemically-defined conditions. My research is focused on the expansion and directed differentiation of human pluripotent stem cells (hPSCs) as 3D suspension aggregates.

Selected Publications
Miranda CC, Fernandes TG, Pascoal JF, Haupt S, Brüstle O, Cabral JMS, Diogo MM (2015) Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment. Biotechnol J, 10: 1612–1624, doi:10.1002/biot.201400846.

Miranda CC, Fernandes TG, Diogo MM, Cabral JMS (2016) Scaling Up a Chemically-Defined Aggregate-Based Suspension Culture System for Neural Commitment of Human Pluripotent Stem Cells. Biotechnol J, 11: 1628-1638, doi: 10.1002/biot.201600446.

Badenes SM, Fernandes TG, Miranda CC, Pusch-Klein A, Haupt S, Rodrigues CA, Diogo MM, Brüstle O, Cabral JM (2017) Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. J Chem Technol Biotechnol, 92: 492–503, doi:10.1002/jctb.5074.

Miranda CC, Fernandes TG, Pinto SN, Prieto M, Diogo MM, Cabral JMS (2018) A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies. Toxicol Lett, 294: p. 51-60, doi:10.1016/j.toxlet.2018.05.018.

Miranda CC, Fernandes TG, Diogo MM, Cabral JMS (2018) Towards Multi-Organoid Systems for Drug Screening Applications. Bioengineering (Basel), 5(3), doi: 10.3390/bioengineering5030049.

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