Dalila Mil-Homens
Post-Doctoral Researcher

Research Activities
My main research area is focused on deepen the role of trimeric autotransporter adhesins on the virulence of Burkholderia cenocepacia. Identify the molecular mechanisms used by this pathogen to adhere, invade and persist in the airways of Cystic Fibrosis patients. Another topic of my research is the study of alternative antimicrobial agents against multiresistant emerging pathogens. I´m also responsible for the management of the Galleria mellonella insect infection model with several collaborations established applying the model to other microorganisms and studying new antibacterial agents.

Selected Publications
Mil-Homens D*, Barahona S*, Moreira RN, Silva IJ, Pinto SN, Fialho AM, Arraiano CM (2018) Stress response protein BolA influences fitness and promotes Salmonella enterica serovar Typhimurium virulence, Appl. Environ. Microbiol. 84(8). doi: 10.1128/AEM.02850-17.*contributed equally

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM (2017) Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation, Cell. Microbiol. 19(4). doi: 10.1111/cmi.12677.

Mil-Homens D, Ferreira-Dias S, Fialho AM (2016) Fish oils against Burkholderia and Pseudomonas aeruginosa: in vitro efficacy and their therapeutic and prophylactic effects on infected Galleria mellonella larvae, J. Appl. Microbiol. 120(6):1509-19. doi: 10.1111/jam.13145.

Mil-Homens D, Leça MI, Fernandes F, Pinto SN, Fialho AM (2014) Characterization of BCAM0224, a multifunctional trimeric autotransporter from the human pathogen Burkholderia cenocepacia, J. Bacteriol. 196(11):1968-79. doi: 10.1128/JB.00061-14.

El-Kirat-Chatel S, Mil-Homens D, Beaussart A, Fialho AM, Dufrêne YF (2013) Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin, Mol. Microbiol. 89(4):649-59. doi: 10.1111/mmi.12301.

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