Paulo Jorge Dias

Research Activities
1. Reconstruction of the evolution of genes involved in the yeast resistance to weak acids and ethanol stress.
2. Evolution of yeast multidrug resistance (MDR) transporters at the amino acid residue level using advanced models of molecular evolution
3. Construction of a dedicated information systems compiling biological and genome information of yeast genes and genomes.
4. Evolutionary comparative analysis of yeast genomes.
5. Toxicogenomics analysis of the physiological consequences of the exposition of yeast cells to the worldwide used agricultural fungicide mancozeb.
6. Flux Balance Analysis Analysis (FBA) and COnstraint-Based Reconstruction and Analysis (COBRA) approaches.

Selected Publications
Godinho CP, Dias PJ, Ponrot E, Sá-Correia I (2018). The paralogous genes PDR18 and SNQ2, encoding ABC multidrug resistance trnsporters, derive from a recent duplication event, PDR18 being specific of the Saccharomyces genus. Frontiers in Genetics. 9: 476. doi: 10.3389/fgene.2018.00476

Palma M, Dias PJ, Roque FC, Luzia L, Guerreiro JF, Sá-Correia I (2017). The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2. BMC Genomics. 18: 75. doi: 10.1186/s12864-016-3443-2

Dias PJ, Sá-Correia I (2014). Phylogenetic and syntenic analyses of the 12-spanner drug:H+ antiporter family 1 (DHA1) in pathogenic Candida species: evolution of MDR1 and FLU1 genes. Genomics. 104: 45-57. doi: 10.1016/j.ygeno.2014.05.005     

dos Santos S, Teixeira MC, Dias PJ, Sá-Correia I (2014). MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches. Frontiers in Physiology (issue on Membrane Physiology and Membrane Biophysics). 5: 180. doi: 10.3389/fphys.2014.00180

Costa C, Dias PJ, Sá-Correia I, Teixeira MC (2014). MFS multidrug transporters in pathogenic fungi: do they have real clinical impact? Frontiers in Physiology (issue on Membrane Physiology and Membrane Biophysics). 5: 197. doi: 10.3389/fphys.2014.00197    

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