Sílvia A. Sousa
Post-Doctoral Researcher



Research Activities
• Identification and exploitation of immunogenic outer membrane proteins of the Burkholderia cepacia complex (Bcc) to design new diagnostic and therapeutic strategies for the prevention of chronic Bcc infections
• Study of Bcc virulence factors as targets for the development of new treatment strategies against Bcc infection
• Role of Hfq, Hfq2 and small non-coding RNAs on the virulence of Bcc
• Use of nematode Caenorhabditis elegans as infection model

Selected Publications
Sousa SA, Seixas AMM, Leitão JH (2018) Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex, Vaccines 6: E34. doi: 10.3390/vaccines6020034

Martina P, Leguizamon M, Prieto CI, Sousa SA, Montanaro P, Draghi WO, Stämmler M, Bettiol M, de Carvalho CCCR, Palau J, Figoli C, Alvarez F, Benetti S, Lejona S, Vescina C, Ferreras J, Lasch P, Lagares A, Zorreguieta A, Leitão JH, Yantorno OM, Bosch A (2018) Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils, Int J Syst Evol Microbiol. 68: 14-20. doi: 10.1099/ijsem.0.002293

Sousa SA, Feliciano JR, Pita T, Guerreiro SI, Leitão JH (2017) Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review, Genes 8: E43. doi: 10.3390/genes8010043

Moreira AS, Mil-Homens D, Sousa SA, Coutinho CP, Pinto-de-Oliveira A, Ramos CG, Dos Santos SC, Fialho AM, Leitão JH, Sá-Correia I (2017) Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection, Virulence 8: 782-796. doi: 10.1080/21505594.2016.1237334

Sousa SA, Morad M, Feliciano JR, Pita T, Nady S, El-Hennamy RE, Abdel-Rahman M, Cavaco J, Pereira L, Barreto C, Leitão JH (2016) The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients, AMB Express 6: 41. doi: 10.1186/s13568-016-0212-1

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ORCID
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